Non-Monotone Response Modules and Cascades from the EML Operator for Reduced Models of Biological Dynamics

Original Abstract

Standard saturating response functions, such as the Hill function, are monotone and therefore cannot represent recruitment-induced overshoot or adaptive transients with a single block. Reproducing such non-monotone responses from saturating primitives requires at least a difference of two blocks with opposing amplitudes, doubling the static-block parameter count. Here, building on a recent mathematical result that a single binary operator, EML, generates all standard elementary functions, we use EML as a structured grammar for reduced nonlinear ODEs. This yields an activation-suppression module that captures overshoot directly. We validate the framework in three settings. First, on PKA-R relocalization data, the EML grammar discovers a reduced surrogate consistent with established mechanistic biology. Second, on Rho-GTPase recruitment data, an exhaustive search over EML expression trees selects the same compositional form across all four perturbation-response traces. Third, a 50-state simulated network is compressed by an EML cascade acting as a fixed temporal basis. Thus we demonstrate the power and potential of EML for reduced models of biological dynamics.